Hemoglobin synthesis in siderocytes of flexed-tailed mutant (f/f) fetal mice
نویسندگان
چکیده
منابع مشابه
Hemoglobin synthesis in siderocytes of flexed-tailed mutant (f/f) fetal mice.
Mice carrying two mutant genes at the f locus on chromosome 1 3 have severe anemia during fetal development, characterized by hypochromic and microcytic red blood cells laden with many iron granules. Ultrastructural studies reveal that the cxcessive nonheme iron accumulated in mutant ( f/f ) fetal erythrocytes is present within mitochondria, similar to those seen in human sideroblastic anemia. ...
متن کاملFetal hemoglobin (HbF) synthesis in baboons, Papio cynocephalus. Analysis of fetal and adult hemoglobin synthesis during fetal development.
Fetal hemoglobin (HbF) and adult hemoglobin (HbA) synthesis was studied in fetal baboons, Papio cynocephalus, to determine the normal pattern of hemoglobin production during fetal development. Fetuses ranging from 53 to 180 days gestation (term gestation 184 days) were used. Erythroid cells were incubated with 3H-L-leucine, and the rates of globin chain synthesis and the distribution of radioac...
متن کاملActivities of haem synthetic enzymes in blood cells of pre-natal flexed-tailed (///) anaemic mice
Levels of activity of 5-aminolaevulinate synthetase, 5-aminolaevulinate dehydratase, porphyrinogen synthetase and haem synthetase in circulating reticulocytes of pre-natal FL4/Re + /+ and congenitally anaemic FLl/Re///mice have been determined. The activities of 5-aminolaevulinate synthetase and 5-aminolaevulinate dehydratase were found to be decreased in proportion to the hypochromia observed ...
متن کاملFetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and beta o-thalassemia.
To determine whether hemoglobin regulation is normal in diseases affecting beta-globin gene expression, globin synthesis was examined in members of a family of a patient with hereditary persistence of fetal hemoglobin/beta o-thalassemia (HPFH/beta o-thal). The HPFH defect is the Ghanian type II, with a deletion from psi beta 1 to at least 20 kb 3' to beta. The beta o-thal gene has the haplotype...
متن کاملFetal Hemoglobin Synthesis in Erythroid Cultures in Hereditary Persistence of Fetal Hemoglobin and @#{176}-Thalassemia
To determine whether hemoglobin regulation is normal in diseases affecting 1-globin gene expression. globin synthesis was examined in members of a family of a patient with hereditary persistence of fetal hemoglobin/fi#{176}-thalassemia (HPFH/$#{176}-thal). The HPFH defect is the Ghanian type II. with a deletion from t’$ to at least 20 kb 3’ to . The / #{176}-thaI gene has the haplotype II restr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1977
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v50.1.165.165